Author

Zhiyun Yu

Cincinnati Children's Hospital Medical CenterORCID 0000-0001-6568-9978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2

Frequent Co-Authors

Mingxia GuiD· 3 shared Minzhe GuoiD· 3 shared Yifei MiaoiD· 3 shared Nicole Min Qian PekiD· 2 shared Victor Pastrana-GomeziD· 2 shared Yu LiuiD· 2 shared Ziyi LiuiD· 2 shared Aaron M. ZorniD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersDevelopmental Biology

Mingxia GuORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioinformaticsNature Cardiovascular ResearchPeer-reviewedJul 24, 2024

APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling

Ziyi Liu, Yu Liu, Zhiyun Yu…·Mingxia Gu

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

18 citationstop 4%

humanscRNA-seq

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Developmental BiologybioRxivPreprintFeb 6, 2024

Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids

Yifei Miao, Cheng Peow Bobby Tan, Nicole Min Qian Pek…·Mingxia Gu

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

8 citations

humanscRNA-seq

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Developmental BiologyCirculation ResearchPeer-reviewedJun 28, 2022

KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome

Zhiyun Yu, Xin Zhou, Ziyi Liu…·Mingxia Gu

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

11 citations

humanscRNA-seq

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