Nicole Min Qian Pek

The paper uses vessel organoids to study how different FOXF1 variants affect mesoderm and capillary development in humans, showing variant-specific disruptions and potential therapeutic rescue.

The paper identifies an NTRK2 isoform switch in BPD lungs that impairs endothelial regeneration and shows that restoring full-length NTRK2 mRNA can reverse alveolar damage.

This study uses metabolically purified human hepatocytes to show that Ebola and Lassa viruses have distinct effects on liver cells.

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.