The paper identifies 27 cyclic dinucleotides that activate STING, showing STING's preference for 2'3'-linked nucleotides and its ability to respond to non-hydrolysable isomers.

bioRxiv · Nov 11, 2025 · PreprintImmunology

Structural Basis for OAS2 Regulation and its Antiviral Function

Veronika Merold, Indra Bekere, Stefanie Kretschmer, Adrian F. Schnell, Dorota Kmieć, Rinu Sivarajan, Katja Lammens, Rou Liu, Julia Mergner, Julia Teppert, Maximilian Hirschenberger, Alexander Henrici, Sarah Hammes, Kathrin Buder, Marcus Weitz, , Carina C. de Oliveira Mann

This study reveals the structural basis of OAS2 regulation and its antiviral function, showing how it discriminates RNA length and restricts viruses like coronaviruses.

Molecular Cell · May 23, 2025Peer-reviewedBiochemistry

ARF1 prevents aberrant type I IFN induction by regulating STING activation and recycling

Maximilian Hirschenberger, Alice Lepelley, Ulrich Rupp, Susanne Klute, Victoria Hunszinger, Lennart Koepke, Veronika Merold, Blaise Didry‐Barca, Fanny Wondany, Tim Bergner, Sebastian Wiese, Stefano Volpi, Marco Gattorno, Riccardo Papa, Sally Ann Lynch, , Konstantin M. J. Sparrer

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.

medRxiv · Apr 28, 2023 · PreprintGenetic & Genomic Medicine