TMPRSS6 cleaves KCNE1 and causes arrhythmias in iron overload disease
Stefan Peischard, Philipp Kastl, Gunnar Goerges, Julian Alexander Schreiber, Arie O. Verkerk, Ronald Wilders, Paul Disse, Isabelle Hornung, Ursula Klingmüller, Andrea Ulrike Steinbicker, Martina Rauner, Maja Vujić Spasić, Frank Rosenbauer, Sven Guenther Meuth, Thomas Budde, , Guiscard Seebohm
This study identifies TMPRSS6 cleavage of KCNE1 as a mechanism causing arrhythmias in iron overload disease using human iPSC-derived cardiomyocytes and computational models.
bioRxiv · Sep 4, 2024 · PreprintPhysiology