Upregulation of ATP-purinergic P2x2 receptors in the cochlea over-amplifies hearing sensitivity leading to hyperacusis and attenuation by antagonists
Tian-Ying Zhai, Chun Liang, Jin Chen…·Hongbo Zhao
This study identifies P2x2 receptor upregulation in the cochlea as a cause of hyperacusis, showing that antagonists can reduce hearing hypersensitivity.