Hongbo Zhao

Spatiotemporal transcriptomic dynamic across the auditory pathway from young to old age in 5xFAD Alzheimer disease mice

The paper analyzes bulk RNA-seq data from multiple auditory regions in 5xFAD mice across ages to identify spatiotemporal gene expression changes associated with AD progression.

Upregulation of ATP-purinergic P2x2 receptors in the cochlea over-amplifies hearing sensitivity leading to hyperacusis and attenuation by antagonists

This study identifies P2x2 receptor upregulation in the cochlea as a cause of hyperacusis, showing that antagonists can reduce hearing hypersensitivity.

Promotion of new expression of connexin gene Cx46 (GJA3) in the cochlea after Cx26 (GJB2) deficiency

This study shows that Cx26 deficiency in the cochlea leads to increased Cx46 expression, which compensates by forming gap junctions in the same locations as Cx26.

ATP-gated P2x7 receptor is a major channel type at type II auditory nerves and required for hearing sensitivity efferent controlling and noise protection

This study identifies the ATP-gated P2x7 receptor as a key channel in type II auditory nerves, showing its role in hearing sensitivity and noise protection through efferent control mechanisms.

Prevention and treatment of noise-induced hearing loss and cochlear synapse degeneration by potassium channel blockers in vivo

This study shows that potassium channel blockers can prevent and treat noise-induced hearing loss and cochlear synapse degeneration when administered before or after noise exposure.

Cx26 heterozygous mutations cause hyperacusis-like hearing sensitivity enhancement and increase susceptibility to noise

This study shows that Cx26 heterozygous mutations increase hearing sensitivity and noise susceptibility, challenging the previous view of their harmlessness.

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer's disease mice

This study uses auditory evoked cortical potentials to detect early functional and cognitive declines in Alzheimer's disease mice, showing changes in peak amplitudes and latencies before clinical symptoms appear.

Excess extracellular K+ causes inner hair cell ribbon synapse degeneration

This study shows that elevated extracellular K+ causes inner hair cell ribbon synapse degeneration, similar to noise-induced synaptopathy, and suggests BK channels as a potential therapeutic target.

Efferent control of hearing sensitivity and protection via inner ear supporting cells

This study shows that MOC efferent nerves also innervate cochlear supporting cells, modulating gap junctions and affecting OHC electromotility, which impacts hearing sensitivity and noise protection.