Tian-Ying Zhai

The paper analyzes bulk RNA-seq data from multiple auditory regions in 5xFAD mice across ages to identify spatiotemporal gene expression changes associated with AD progression.

This study identifies P2x2 receptor upregulation in the cochlea as a cause of hyperacusis, showing that antagonists can reduce hearing hypersensitivity.

This study shows that Cx26 deficiency in the cochlea leads to increased Cx46 expression, which compensates by forming gap junctions in the same locations as Cx26.

This study identifies the ATP-gated P2x7 receptor as a key channel in type II auditory nerves, showing its role in hearing sensitivity and noise protection through efferent control mechanisms.

This study shows that potassium channel blockers can prevent and treat noise-induced hearing loss and cochlear synapse degeneration when administered before or after noise exposure.