Angelike Stathopoulos

The paper shows that high Dorsal levels suppress snail expression by limiting enhancer activity, while low levels promote it, through dynamic regulation of enhancer interactions.

The paper uses optogenetics to manipulate Dorsal levels in Drosophila embryos, revealing a critical temporal window for its function in patterning and transcriptional regulation.

This study compares the effects of acute Dorsal level reduction via nuclear export versus degradation on target gene expression in Drosophila embryos.

The paper shows that Odd-paired (Opa) acts as a late-acting pioneer factor that coordinates with Zelda to regulate gene expression in early Drosophila embryos.