Virginia L Pimmett

Coordinated active repression operates via transcription factor cooperativity and multiple inactive promoter states in a developing organism.

The paper investigates how Snail-mediated repression coordinates cell fate decisions through transcription factor cooperativity and multiple inactive promoter states during development.

Spatio-temporal control of nuclear mechanotransduction during Epithelial-to-Mesenchymal Transition

The paper investigates how nuclei respond to mechanical forces during EMT using Drosophila mesoderm invagination, showing spatially distinct transcriptional responses.

Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription

The paper uses optogenetics to manipulate Dorsal levels in Drosophila embryos, revealing a critical temporal window for its function in patterning and transcriptional regulation.

Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

The paper uses live imaging and computational methods to study how promoter motifs affect transcriptional bursting in Drosophila embryos, revealing distinct dynamics for TATA and INR motifs.