Jessie J.F. Medeiros

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

SmMIP-tools processes and analyzes smMIP-derived sequencing data, enabling accurate variant detection and improving accessibility to smMIP technology for genetic research.

The paper identifies microhomology-mediated end joining (MMEJ) as the mechanism behind recurrent deletions in myeloid malignancies and shows that these deletions occur in multipotent hematopoietic stem cells.