Author

David Kealy

University of YorkORCID 0000-0001-9246-8134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andrew N. HoldingiD· 2 shared Katherine S. BridgeiD· 2 shared Adam C. WilkinsoniD· 1 shared Adam DowleiD· 1 shared Adele Kay FieldingiD· 1 shared Alexandra Misura· 1 shared Andrew S. MasoniD· 1 shared Andy G.X. ZengiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Andrew N. HoldingORCID

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3 papers

Recent·Most cited

Cancer BiologyBloodPeer-reviewedJun 20, 2026

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS

He Tian Chen, Pratik Joshi, Séverine Cathelin…·Kristin J. Hope

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

2 citationstop 4%

humanbulk RNA-seq

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Cancer BiologyLeukemiaPeer-reviewedFeb 2, 2026

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

David Kealy, Ruth Ellerington, Suraj Bansal…·Katherine S. Bridge

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

6 citationstop 1%

humanbulk RNA-seq

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Molecular BiologyPLoS PathogensPeer-reviewedJun 6, 2022

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication but essential for the production of infectious virus.

Joseph C. Ward, Lidia Lasecka‐Dykes, Chris Neil…·Nicola J. Stonehouse

This study shows that RNA pseudoknots in FMDV are not required for genome replication but are essential for producing infectious virus.

17 citations

experimental assay

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