Jihad Aburas

This study uses C. elegans models to show that eIF2D is essential for RAN translation in C9orf72 expansions, and its inhibition extends lifespan and reduces disease.

The paper identifies direct targets of the terminal selector UNC-3 in C. elegans motor neurons and shows that its function is temporally modular, with distinct roles in maintaining neuronal identity across life stages.

The paper identifies a terminal selector that prevents a Hox transcriptional switch to maintain motor neuron identity in C. elegans.

This study identifies the role of COE-type transcription factors in axial motor neuron development across species, showing functional conservation and specific requirements for Ebf1 and Ebf2 in mice and nematodes.