Author

Andrew C. Fleming

Northwestern UniversityORCID 0000-0002-5889-871XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Evangelos KiskinisiD· 3 shared André EX BrowniD· 1 shared Eleanor C. WarreniD· 1 shared Elizabeth L. DaleyiD· 1 shared Eric Nathaniel AndersoniD· 1 shared Fen‐Biao GaoiD· 1 shared Ghanashyam D. GhadgeiD· 1 shared Gopinath KrishnaniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Evangelos KiskinisORCID

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Author profile →

3 papers

Recent·Most cited

The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

Andrew C. Fleming, Nalini R. Rao, Matthew Wright, Jeffrey N. Savas, Evangelos Kiskinis

This study identifies DNAJC7 as a mediator of neuroprotection in ALS by modulating HSF1 activity and shows that HSF1 expression can rescue proteotoxic stress in mutant DNAJC7 neurons.

bioRxiv · Dec 1, 2024 · PreprintNeuroscience

CLIP-Seq Analysis Enables the Design of Ribosomal RNA Bait Oligonucleotides That Protect Against C9orf72 ALS/FTD-Associated Poly-GR Pathophysiology

Juan Alberto Ortega, Ivan R. Sasselli, Marco Boccitto, Andrew C. Fleming, Tyler R. Fortuna, Yichen Li, Kohei Sato, Tristan D. Clemons, Elizabeth L. Daley, Thao Phuong Nguyen, Eric Nathaniel Anderson, Justin K. Ichida, Udai Bhan Pandey, Sandra L. Wolin, Samuel Isaac Stupp, Evangelos Kiskinis

The paper identifies that poly-GR binds ribosomal RNA and shows that modified rRNA oligonucleotides can mitigate poly-GR toxicity in models of C9orf72 ALS/FTD.

bioRxiv · Dec 30, 2022 · PreprintNeuroscience

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

Yoshifumi Sonobe, Jihad Aburas, Gopinath Krishnan, Andrew C. Fleming, Ghanashyam D. Ghadge, Priota Islam, Eleanor C. Warren, Yuanzheng Gu, Mark W. Kankel, André EX Brown, Evangelos Kiskinis, Tania F. Gendron, Fen‐Biao Gao, Raymond P. Roos, Paschalis Kratsios

This study uses C. elegans models to show that eIF2D is essential for RAN translation in C9orf72 expansions, and its inhibition extends lifespan and reduces disease.

Nature Communications · Oct 15, 2021Peer-reviewedNeuroscience