Yoshifumi Sonobe

Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

The paper identifies AUG initiation codons for antisense DPRs in C9ORF72-ALS/FTD, showing redundancy in start codon usage and distinct translation factors for sense and antisense transcripts.

Machine learning predicts translation initiation sites in neurologic diseases with expanded repeats

The paper develops improved machine learning models to predict translation initiation sites in neurologic diseases with expanded repeats, achieving higher accuracy than previous methods.

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

This study uses C. elegans models to show that eIF2D is essential for RAN translation in C9orf72 expansions, and its inhibition extends lifespan and reduces disease.

RNA-binding protein altered expression and mislocalization in multiple sclerosis

The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.