Paschalis Kratsios

This study identifies PBX-dependent and independent Hox gene interactions that establish and maintain motor neuron subtype identity in C. elegans.

This study shows that negative autoregulation of the TF UNC-3 maintains precise expression levels in post-mitotic neurons, counterbalanced by positive input from CEH-20/PBX, ensuring cell identity.

The paper identifies both cell-autonomous and non-cell-autonomous roles of UNC-3 in C. elegans motor neurons, revealing its impact on neuronal identity and downstream connectivity.

This study identifies transcription factor feedback loops that maintain and restore touch sensation in C. elegans by securing interneuron identity and function.

This study identifies the conserved role of HOX proteins in regulating Iro/Irx gene expression during motor neuron development in mice and C. elegans.

This study shows UNC-30/PITX regulates GABA receptor clustering and biosynthesis in C. elegans motor neurons through transcriptional control of target genes.

This paper evaluates the efficacy of auxin-inducible degradation in C. elegans using different auxins and TIR1-expressing strains to deplete specific proteins.

The paper identifies AUG initiation codons for antisense DPRs in C9ORF72-ALS/FTD, showing redundancy in start codon usage and distinct translation factors for sense and antisense transcripts.

The paper creates a molecular atlas of adult C. elegans motor neurons, identifying 29 subclasses defined by transcription factor and neuropeptide codes, and shows conservation between C. elegans and mice.

This study identifies CFI-1 as a key regulator of neuronal terminal differentiation in C. elegans, revealing context-dependent activation and repression mechanisms in different neuron types.

The paper shows that Hox proteins maintain neurotransmitter identity in C. elegans motor neurons through a homeostatic mechanism involving a positive feedforward loop and negative feedback.

The paper investigates the role of homeobox genes in neuronal identity specification in C. elegans, finding that 111 of 118 neuron classes require homeobox genes for proper differentiation.

The paper investigates the role of Hoxc8 in maintaining terminal differentiation of spinal motor neurons in mice, showing its necessity for expression of differentiation markers and uncovering new regulatory relationships.

The paper shows that BAF and PBAF SWI/SNF complexes differentially regulate cell cycle arrest and invasion in C. elegans anchor cells.

This study uses C. elegans models to show that eIF2D is essential for RAN translation in C9orf72 expansions, and its inhibition extends lifespan and reduces disease.

The paper identifies direct targets of the terminal selector UNC-3 in C. elegans motor neurons and shows that its function is temporally modular, with distinct roles in maintaining neuronal identity across life stages.

The paper identifies a terminal selector that prevents a Hox transcriptional switch to maintain motor neuron identity in C. elegans.

This study identifies the role of COE-type transcription factors in axial motor neuron development across species, showing functional conservation and specific requirements for Ebf1 and Ebf2 in mice and nematodes.