Andrea Santuy

The paper introduces a tracing method to quantify brain connectivity by skeletonizing nerve fibers and analyzing synaptic contacts across different brain regions.

This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.

The paper estimates synapse numbers in the hippocampus and brain-wide using electron microscopy and genetic labeling, finding high densities in isocortex and olfactory areas, and low densities in pallidum and cerebellum.

The paper reveals structural differences in thalamocortical synapses between motor and somatosensory cortices, suggesting subcellular complexity in neural circuits.