Nikolas Layer

Local translation drives glioblastoma heterogeneity and tumor invasion

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndrome

This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.

Dravet variant SCN1AA1783V impairs interneuron firing predominantly by altered channel activation

This paper characterizes the functional impact of the SCN1AA1783V variant in Dravet syndrome by combining electrophysiology, computational modeling, and in vitro validation, showing impaired interneuron firing due to altered channel activation.

Human cerebrospinal fluid induce neuronal excitability changes in resected human neocortical and hippocampal brain slices

This study shows that human cerebrospinal fluid (hCSF) increases neuronal activity and network reconfiguration in human brain slices compared to artificial cerebrospinal fluid (aCSF).