This paper benchmarks axon length estimation tools using simulated and real data to evaluate accuracy, efficiency, and practicality for different research contexts.

PLoS Computational Biology · Dec 8, 2021Peer-reviewedNeuroscience

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy

Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández‐Mendívil, Ángel Núñez, Marta del Campo, César Porrero, Nuria García‐Magro, Pilar Negredo, Cristina Sánchez‐Ramos, Juan Antonio Bernal, Alberto Rábano, Jeroen J.M. Hoozemans, Ana Isabel Casas, Harald H.H.W. Schmidt, Ana María Cuervo, Manuela G. López

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

bioRxiv · Oct 14, 2020 · PreprintNeuroscience

Area-specific synapse structure in branched axons reveals a subcellular level of complexity in thalamocortical networks

Javier Rodriguez-Moreno, César Porrero, Astrid Rollenhagen, Mario Rubio-Teves, Diana Casas-Torremocha, Lidia Alonso‐Nanclares, Rachida Yakoubi, Andrea Santuy, Ángel Merchán-Pérez, Javier DeFelipe, Joachim H. R. Lübke, Francisco Clascá

The paper reveals structural differences in thalamocortical synapses between motor and somatosensory cortices, suggesting subcellular complexity in neural circuits.

Journal of Neuroscience · Feb 13, 2020Peer-reviewedNeuroscience