Ángel Merchán-Pérez

This paper establishes a workflow for applying volume electron microscopy to human cortical organoids, enabling micro-connectomic reconstruction at nanometer resolution.

The paper introduces a tracing method to quantify brain connectivity by skeletonizing nerve fibers and analyzing synaptic contacts across different brain regions.

The paper quantifies synaptic characteristics in the Etruscan shrew's cortex, finding high synaptic density and similar organization to humans despite significant differences in brain size and synapse number.

The paper estimates synapse numbers in the hippocampus and brain-wide using electron microscopy and genetic labeling, finding high densities in isocortex and olfactory areas, and low densities in pallidum and cerebellum.

The paper reveals structural differences in thalamocortical synapses between motor and somatosensory cortices, suggesting subcellular complexity in neural circuits.