Thomas V. Wuttke

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

This study investigates the developmental impact of KCNQ2 loss-of-function variants in patient iPSC-derived neurons, showing reduced M-currents and disrupted oscillatory activity linked to developmental delay and seizures.

This study analyzes human dendritic spine morphology and density using a unique dataset and deep learning, revealing sex and tissue-specific differences and changes over time in culture.

The paper analyzes Ca2+ signaling in human microglia and finds differences in signal properties across morphotypes.

This paper provides a detailed protocol for long-term human organotypic brain slice cultures, enabling extended electrophysiological studies and viral transduction.

This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.

This paper characterizes the functional impact of the SCN1AA1783V variant in Dravet syndrome by combining electrophysiology, computational modeling, and in vitro validation, showing impaired interneuron firing due to altered channel activation.

This study shows that human cerebrospinal fluid (hCSF) increases neuronal activity and network reconfiguration in human brain slices compared to artificial cerebrospinal fluid (aCSF).