Author

Alexis Penverne

The Francis Crick InstituteORCID 0000-0001-8980-837XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hannah J Lucas-ClarkeiD· 2 shared James R. EvansiD· 2 shared Karishma D’SaiD· 2 shared Patricia Lopez-GarciaiD· 2 shared Sonia GandhiiD· 2 shared Stephanie StrohbueckeriD· 2 shared Aine Fairbrother-BrowneiD· 1 shared Alex GriffithsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Hannah J Lucas-ClarkeORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 13, 2025

The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis

Laura Mahoney‐Sanchez, Hannah J Lucas-Clarke, Alexis Penverne…·Sonia Gandhi

This study shows that the SNCA A53T mutation increases vulnerability to ferroptosis in neurons and microglia, suggesting 15-LO inhibition as a potential therapeutic target for Parkinson's disease.

1 citation

humanproteomics

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NeurosciencebioRxivPreprintAug 25, 2025

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease

James R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith…·Sonia Gandhi

The paper identifies microglial activation and alpha-synuclein oligomers as drivers of early neuroinflammation in Parkinson's disease using transcriptomic and aggregate profiling in early-stage brain samples.

5 citations

humanbulk RNA-seq

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