Molecular BiologyNaturePeer-reviewed
Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes
Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie…·Ning Zheng
This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.
59 citationstop 1%