Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders
Pallavi M. Gosavi, Kevin Chun-Ho Ngan, Megan J. R. Yeo, Cindy Su, Jiaming Li, Nicholas Z. Lue, Samuel M. Hoenig, Brian B. Liau
This study identifies drug resistance mutations in neosubstrates of molecular glue degraders using CRISPR-suppressor scanning and reveals common resistance mechanisms.
ACS Central Science · Feb 14, 2022Peer-reviewedMolecular Biology