Mingxi Deng

This study identifies H2B.W2 as a spermatocyte-specific histone variant that destabilizes nucleosomes and reduces chromatin compaction, potentially regulating gene expression during spermatogenesis.

The paper reports seven individuals with PLCG1 variants causing hearing, vision, cardiac, and immune issues, and shows these variants have gain-of-function effects in Drosophila models.

The paper identifies Upd2 as a critical factor promoting tumorous growth by converging oncogenic Ras, Yki, and Notch signals in Drosophila imaginal discs.

This study identifies common metabolic and epigenetic changes in fly and human tumors, showing that metabolite depletion drives tumorigenesis across species.

This study shows that Drosophila scrib mutant tumors transition from a growth arrest to a proliferative state over time, suggesting potential for tumor evolution.