Author

Alex J Kaiser

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Abigail KellyiD· 2 shared Andrew NelsoniD· 2 shared Barry L. StoddardiD· 2 shared Brett K. KaiseriD· 2 shared Jennifer J. ReadshawiD· 2 shared Julieta Peralta AcostaiD· 2 shared Lindsey DoyleiD· 2 shared Maria Puiu· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Abigail KellyORCID

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2 papers

Recent·Most cited

Competing forms of protein-protein association and DNA binding exhibited by BrxC from the BREX phage restriction system

Alex J Kaiser, Jennifer J. Readshaw, Lindsey Doyle, Maria Puiu, Abigail Kelly, Sydney F. McGuire, Julieta Peralta Acosta, Duc Vu, Andrew Nelson, Darren L. Smith, Lidia Araújo‐Bazán, Ernesto Arias‐Palomo, Yvette A. Luyten, Barry L. Stoddard, Tim R. Blower, Brett K. Kaiser

This study investigates the structural and functional properties of BrxC, a conserved AAA+ ATPase in the BREX phage restriction system, revealing its role in mediating competing protein associations and DNA binding that regulate host methylation and phage restriction.

bioRxiv · Apr 11, 2026 · PreprintBiochemistry

PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB

Jennifer J. Readshaw, Lindsey Doyle, Maria Puiu, Abigail Kelly, Andrew Nelson, Alex J Kaiser, Sydney F. McGuire, Julieta Peralta Acosta, Darren Smith, Barry L. Stoddard, Brett K. Kaiser, Tim R. Blower

This study identifies and characterizes the PglZ:BrxB sub-complex of BREX phage defence systems, revealing PglZ as a metal-dependent nuclease that contributes to phage defence.

Nucleic Acids Research · Jun 4, 2025Peer-reviewedBiochemistry