Sabine Klein

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

The paper refines enterotypes in global fecal metagenomes using fuzzy clustering and introduces an Enterotype Dysbiosis Score to assess disease associations.

The paper quantifies the human liver proteome at cell-type resolution across multiple conditions, revealing proteome changes in disease states and providing a web-based resource for exploration.

This study identifies a molecular pathway involving ARRB2 and RARRES1 that regulates the transition from liver fibrosis to cancer, with implications for diagnostics and therapeutics.