Flávia Rezende

This paper identifies immunomodulatory endothelial cells (IMEC) that present antigens on MHC class II and activate T cells in atherosclerosis.

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.

The paper identifies HIF1α-AS1 as a DNA:DNA:RNA triplex-forming lncRNA that interacts with the HUSH complex to repress gene expression and modulates angiogenesis in pulmonary hypertension.