Andrew E. Prendergast

Latrophilin-2 Orchestrates Endothelial Flow-Mediated Smad1/5 Activation via Endoglin and Shank3

This paper identifies Latrophilin-2 as a mediator of flow-induced Smad1/5 activation in endothelial cells through interactions with Endoglin and Shank3, independent of G-proteins.

Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction

This study identifies latrophilins as essential for endothelial cell mechanotransduction of fluid shear stress through both G protein-dependent and -independent pathways.

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

This study identifies Pkd2l1 as essential for mechanosensation in cerebrospinal fluid-contacting neurons and spine curvature maintenance in zebrafish.