Pratik Datta

This study identifies PspA's role in maintaining membrane potential and supporting NADH dehydrogenase function in mycobacteria through interactions with PspM and menaquinone.

This paper describes the discovery of TXA11114, an efflux pump inhibitor that enhances levofloxacin efficacy against multidrug-resistant Pseudomonas aeruginosa in vivo with a safe toxicology profile.

The paper identifies novel partners and evolutionary history of phage shock protein (PSP) systems across bacteria, showing their presence in LUCA and diversification into new functional contexts.

The paper investigates stress-sensing mechanisms in Mycobacterium tuberculosis and M. smegmatis, showing hysteresis in pathogenic bacteria and revealing the role of DnaK in enabling fast and sustained responses.