Xiaoyun Wu

This study examines how high concentrate diets affect Yak jejunal structure, function, and protein composition during cold seasons, finding differences in enzyme activity, morphology, and protein expression between grazing and intensive feeding.

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.

The paper uses morphological profiling to identify gene function and connectivity, revealing TRAF2/C-REL's negative regulation of Hippo pathway effectors.