Brenda Leyva Garcia

Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome

This study examines chandelier cell excitability in Dravet Syndrome mice, finding impaired excitability in juvenile and adult stages, distinct from basket cells.

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.

The paper identifies a novel inhibitory interneuron subtype in the dentate gyrus that selectively regulates mossy cell function and shows this pattern is evolutionarily conserved across species.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.