Keenan S. Pearson

In Vivo Selection of anti-glioblastoma DNA aptamer-drug conjugates in an orthotopic patient-derived xenograft model

This study develops and tests DNA aptamer-drug conjugates (ApDCs) for glioblastoma treatment using an in vivo SELEX approach in a patient-derived xenograft model.

Defining the DNA Binding Specificity of GRHL2

This study defines the DNA binding specificity of GRHL2 using a high-density genomic SNAP array, revealing sequence rules and flanking sequence influences.

Acetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activity

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

An unbiased cell-culture selection yields DNA aptamers as novel senescent cell-specific reagents

This study uses unbiased cell culture selections to identify DNA aptamers specific to senescent cells, demonstrating their utility as reagents for detecting senescent cells in vitro and in tissues.

DNA aptamers that modulate biological activity of model neurons

The paper demonstrates the feasibility of identifying biologically active DNA aptamers that modulate the activity of human SH-SY5Y neuroblastoma cells.