Taylor Malachowski

Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy

This study identifies senescent peripheral fibroblasts as the initiators of chemotherapy-induced peripheral neuropathy, showing that targeting MK2 in these cells can prevent and reverse the condition.

Myofibroblastic CAFs arising from bone-resident osteoblast precursors retain an osteolineage signature and support breast cancer progression via Osterix-mediated signaling.