Author

Karsten D. Householder

Stanford MedicineORCID 0000-0003-0282-4479Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

Arthur DengiD· 1 shared K. Christopher GarcíaiD· 1 shared Kevin M. JudeiD· 1 shared Matthias ObenausiD· 1 shared Nan WangiD· 1 shared Steven C. WilsoniD· 1 shared Xiaojing Tina CheniD· 1 shared Xinyu XiangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Arthur DengORCID

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1 paper

Recent·Most cited

ImmunologySciencePeer-reviewedJul 24, 2025

✦ In-depth digest

De novo design and structure of a peptide-centric TCR mimic binding module

Karsten D. Householder, Xinyu Xiang, Kevin M. Jude…·K. Christopher García

A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.

43 citationstop 1%

humanstructural biology

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