Author

Sita Shah

Queen Mary University of LondonORCID 0000-0001-6854-4133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew V. StachulskiiD· 2 shared Lesley HoylesiD· 2 shared Simon McArthuriD· 2 shared Tobias B-A. Knausenberger· 2 shared David VauzouriD· 1 shared David W. Randall· 1 shared Egle SolitoiD· 1 shared Emily ConnelliD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Andrew V. StachulskiORCID

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2 papers

Recent·Most cited

Systems BiologyGut MicrobesPeer-reviewedNov 24, 2024

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor

Sita Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex…·Simon McArthur

This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.

29 citations

𝕏 PostBluesky

Systems BiologyTissue BarriersPeer-reviewedMay 20, 2022

A host-gut microbial co-metabolite of aromatic amino acids, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo

Andrew V. Stachulski, Tobias B-A. Knausenberger, Sita Shah…·Simon McArthur

This study shows that p-cresol glucuronide, a host-gut microbial co-metabolite, reduces blood-brain barrier permeability and modulates brain transcriptome expression in mice.

61 citationstop 4%

mousebulk RNA-seq

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