Systems BiologyGut MicrobesPeer-reviewed
Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor
Sita Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex…·Simon McArthur
This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.