Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor
Sita Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex, Emily Connell, Gwénaëlle Le Gall, Tom A. J. Hardy, David W. Randall, Kieran McCafferty, Muhammad Magdi Yaqoob, Egle Solito, Michael M. Müller, Andrew V. Stachulski, Robert Charles Glen, David Vauzour, Lesley Hoyles, Simon McArthur
This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.
Gut Microbes · Nov 24, 2024Peer-reviewedSystems Biology