Annie M. Dosey

The paper identifies molecular interactions between influenza HAs and MHC-II, showing avian MHC-II enables more efficient entry than human MHC-II for most H5 HAs and reveals structural and functional similarities across different HA subtypes.

This paper designs de novo protein nanoparticles with integrated functional motifs, demonstrating their ability to form structured assemblies and elicit immune responses in mice.

This paper designs self-assembling protein nanoparticle vaccines using AlphaFold2 predictions, demonstrating atomic-level accuracy and potent immune responses in mice.

Stabilizing H5 HA mutations enhance neutralizing antibody responses by shifting epitope targeting toward the receptor binding site in vaccinated mice.

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

This paper introduces a top-down reinforcement learning approach to design protein nanomaterials, resulting in more compact and robust icosahedral assemblies than previously observed.