Cole A. DeForest

This paper introduces FRET biosensors that use Boolean logic to detect multiple protein inputs simultaneously in complex environments.

This study evaluates an intratumoral B7H3:CD3 TCE in canine sarcoma patients, showing localized T-cell accumulation without systemic toxicity.

This paper introduces a step-emulsion platform for scalable microgel fabrication that is robust, user-agnostic, and compatible with various materials and viscosities.

This study investigates thiol-ene crosslinking dynamics in hyaluronic acid hydrogels to optimize network properties for in vitro tissue modeling.

This paper designs de novo protein nanoparticles with integrated functional motifs, demonstrating their ability to form structured assemblies and elicit immune responses in mice.

This paper designs self-assembling protein nanoparticle vaccines using AlphaFold2 predictions, demonstrating atomic-level accuracy and potent immune responses in mice.

The paper introduces STEAM, a microfluidic platform for creating suspended tissue constructs with spatial patterning and mechanical manipulation capabilities, demonstrating its use in engineered muscle tissue.

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

The paper introduces STOMP, a method to create multi-regional suspended tissues for studying complex tissue interfaces, and reports altered contractile dynamics in engineered heart tissues and bone-ligament constructs.

This paper introduces a hydrogel platform with reversible stiffness tuning and cell recovery capabilities to study mechanobiological effects on cell behavior and transcriptome responses.

This paper introduces GIZMO, a method to create 3D grayscale hydrogel patterns for more realistic tissue engineering.