Author

Jackson McGowan

University of WashingtonORCID 0009-0002-6418-3371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1

Frequent Co-Authors

Elizabeth M. LeafiD· 4 shared Neil P. KingiD· 4 shared Annie M. DoseyiD· 3 shared Masaru KanekiyoiD· 3 shared Cole A. DeForestiD· 2 shared Cyrus M. HaasiD· 2 shared Emily Grey· 2 shared Rashmi RavichandraniD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiochemistry

Elizabeth M. LeafORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo design of protein nanoparticles with integrated functional motifs

Cyrus M. Haas, Sanela Rankovic, Hanul K Lewis, Kenneth D. Carr, Connor Weidle, Sophie S Gerdes, L. Nuss, Felicitas Ruiz, Syed Moiz, Maggie Fiorelli, Emily Grey, Jackson McGowan, N. Pavan Kumar, Adrian Creanga, Alex Kang, , Neil P. King

This paper designs de novo protein nanoparticles with integrated functional motifs, demonstrating their ability to form structured assemblies and elicit immune responses in mice.

bioRxiv · Jan 2, 2026 · PreprintBiochemistry

From sequence to scaffold: computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks

Cyrus M. Haas, Naveen Jasti, Annie M. Dosey, Joel D. Allen, Rebecca A. Gillespie, Jackson McGowan, Elizabeth M. Leaf, Max Crispin, Cole A. DeForest, Masaru Kanekiyo, Neil P. King

This paper designs self-assembling protein nanoparticle vaccines using AlphaFold2 predictions, demonstrating atomic-level accuracy and potent immune responses in mice.

Proceedings of the National Academy of Sciences · Nov 3, 2025Peer-reviewedBiochemistry

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses

Annie M. Dosey, Bernadeta Dadonaite, Rebecca A. Gillespie, Elizabeth M. Leaf, Matthew J. Vukovich, Jackson McGowan, Emily Grey, Hiromi Muramatsu, Rachel H. J. Jun, Norbert Pardi, Masaru Kanekiyo, Jesse D. Bloom, Neil P. King

Stabilizing H5 HA mutations enhance neutralizing antibody responses by shifting epitope targeting toward the receptor binding site in vaccinated mice.

bioRxiv · Jul 30, 2025 · PreprintImmunology

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

Cara W. Chao, Kaitlin R. Sprouse, Marcos C. Miranda, Nicholas J. Catanzaro, Miranda L. Hubbard, Amin Addetia, Cameron Stewart, Jack T. Brown, Annie Dosey, Adian Valdez, Rashmi Ravichandran, Grace G. Hendricks, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, , Neil P. King

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

bioRxiv · Mar 13, 2024Immunology