Luis Fernando Santana

Quantitative Head-to-Tail Analysis Reveals Heterogeneous Cellular Organization and Connexin Expression in the Porcine Sinoatrial Node

The paper quantifies cellular organization and connexin expression in the porcine sinoatrial node, revealing regional differences in pacemaking function and current source-sink relationships.

Endogenous subthreshold noise and PIP2 tune diastolic coherence across the intact sinoatrial node through stochastic resonance

This study shows that endogenous noise and PIP2 modulate diastolic coherence in the sinoatrial node through stochastic resonance, with coherence peaking at intermediate noise levels.

Intracellular Mechanosensation in Intestinal Smooth Muscle: Piezo1 Complexes Amplify Signaling Beyond the Surface

This paper identifies an intracellular mechanosensory complex in intestinal smooth muscle that amplifies signaling from the sarcoplasmic reticulum, independent of extracellular calcium, to regulate contractility.

From Lipid Dynamics to Precision Predictions: A New Approach Methodology for Precision Modeling of Phosphoinositide Signaling

This paper develops a new methodology to model phosphoinositide signaling dynamics, showing that basal PI(4)P levels determine cell-specific responses to genetic perturbations.

Beat-locked ATP microdomains in the sinoatrial node map a calcium-timed energetic hierarchy and regional pacemaker roles

The paper tracks beat-resolved ATP dynamics in mouse sinoatrial node myocytes, revealing distinct ATP-gain and -dip modes linked to regional pacemaker roles and energy supply.

Large-scale synthetic data enable digital twins of human excitable cells

The paper uses synthetic data to create digital twins of human cardiomyocytes, enabling precise modeling of electrophysiological properties from experimental recordings.

Demonstration of Beat-to-Beat, On-Demand ATP Synthesis in Ventricular Myocytes Reveals Sex-Specific Mitochondrial and Cytosolic Dynamics.

This paper visualizes beat-to-beat ATP dynamics in ventricular myocytes of male and female mice, revealing sex-specific mitochondrial and cytosolic ATP production strategies.

SanPy: A whole-cell electrophysiology analysis pipeline.

SanPy is a Python-based open-source pipeline for analyzing whole-cell current-clamp recordings, providing tools for parameter extraction, visualization, and quality control.

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in neurons

The paper identifies Kv2.1's role in clustering and functional coupling of L-type Ca2+ channels and RyR channels at ER-PM junctions, enabling localized Ca2+ release independent of action potentials.

A toolbox of nanobodies developed and validated for diverse neuroscience research applications

The paper develops and validates a set of nanobodies for targeting proteins in brain neurons, providing a toolbox for visualization and modulation of subcellular sites.