Frédéric Luton

This study shows that basement membrane turnover and filopodia can drive protease-independent invasion through mechanical deformation and pore enlargement.

This study shows that inhibiting PTCH1 drug efflux improves chemotherapy effectiveness in triple-negative breast cancer cells by increasing drug retention and reducing cell migration.

The paper uses 3D spheroid models to show filopodia-like protrusions help breast cancer cells invade by widening basement membrane pores.

This study shows Arf6 is required downstream of Armadillo/β-catenin stabilization for high-level Wingless signaling in Drosophila wing development.