The paper identifies and characterizes extracellular vesicles (EVs) released by zoospores of Phytophthora parasitica, revealing their molecular composition and potential role in intercellular communication.

bioRxiv · Sep 13, 2026 · PreprintMolecular Biology

Human mammary 3D spheroid models uncover the role of filopodia in breaching the basement membrane to facilitate invasion

Alain Corinus, Sophie Abélanet, Julia Dubreuil, Zhenyu Zhu, Sabrina Pisano, Christelle Boscagli, Anne-Sophie Gay, Delphine Debayle, Marin Truchi, Kévin Lebrigand, Sandra Lacas‐Gervais, Frédéric Brau, Xavier Descombes, Patricia Rousselle, Michel Franco, Frédéric Luton

The paper uses 3D spheroid models to show filopodia-like protrusions help breast cancer cells invade by widening basement membrane pores.

Matrix Biology · Dec 2, 2025Peer-reviewedCell Biology

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

Fanny Eysert, Véronique Legros, Anne-Sophie Gay, Delphine Debayle, Sandra Lacas‐Gervais, Guillaume Chevreux, Michel Bottlaender, Guillaume Dorothée, Frédéric Checler, Marie-Claude Potier, Marie Sarazin, Julien Lagarde, Mounia Chami

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

bioRxiv · Jan 8, 2025 · PreprintNeuroscience