Human mammary 3D spheroid models uncover the role of filopodia in breaching the basement membrane to facilitate invasion
Alain Corinus, Sophie Abélanet, Julia Dubreuil, Zhenyu Zhu, Sabrina Pisano, Christelle Boscagli, Anne-Sophie Gay, Delphine Debayle, Marin Truchi, Kévin Lebrigand, Sandra Lacas‐Gervais, Frédéric Brau, Xavier Descombes, Patricia Rousselle, Michel Franco, Frédéric Luton
The paper uses 3D spheroid models to show filopodia-like protrusions help breast cancer cells invade by widening basement membrane pores.
Matrix Biology · Dec 2, 2025Peer-reviewedCell Biology