HDAC inhibitor treatment restores transcriptome, chromatin accessibility and memory deficits in a mouse model for Down syndrome
Cèsar Sierra, René A. J. Crans, Mara Dierssen
iScience · Sep 30, 2026Peer-reviewedMolecular Biology
Author
Cèsar Sierra
Barcelona Institute of Science and TechnologyORCID 0000-0002-4544-9149Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 1/yrCo-Author Collaboration Network
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A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation
Patryk Poliński, Marta Miret-Cuesta, Alfonsa Zamora‐Moratalla, Federica Mantica, Gerard Cantero-Recasens, Carlotta Viana, Miguel Sabariego-Navarro, Davide Normanno, L. Iñiguez, Sophie Bonnal, Raúl Gómez-Riera, Hugo Fanlo-Ucar, Dominic S. Yap, María Martínez de Lagrán Cabredo, Álvaro Fernández‐Blanco, , Manuel Irimia
Repositori digital de la UPF (Universitat Pompeu Fabra) · Jan 1, 2025Peer-reviewedNeuroscience
Single nucleus RNA-seq in the hippocampus of a Down syndrome mouse model reveals new key players in memory
Cèsar Sierra, Miguel Sabariego-Navarro, Álvaro Fernández‐Blanco, Sonia Cruciani, Alfonsa Zamora‐Moratalla, Eva Maria Novoa, Mara Dierssen
The paper uses single nucleus RNA-seq to analyze the hippocampus of a Down syndrome mouse model, identifying transcriptomic changes and a novel long-non-coding gene involved in cognitive phenotypes.
Molecular Psychiatry · Feb 26, 2024Peer-reviewedNeuroscience