Karla M. Ramos‐Torres

Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP

This study evaluates [18F]3F4AP PET imaging for detecting demyelination in traumatic brain injury models in mice, showing increased tracer uptake correlating with histological evidence of myelin loss.

Imaging demyelinated axons after spinal cord injuries with PET tracer 3F4AP

This study introduces a PET tracer, [18F]3F4AP, to image demyelinated axons in spinal cord injuries and shows its ability to detect injury and monitor changes in animal models and humans.

Synthesis of K+ channel radioligand 5-methyl-3-fluoro-4-aminopyridine and PET imaging in mice

This paper synthesizes [18F]5Me3F4AP, a K+ channel PET radioligand, and demonstrates its brain uptake and kinetics in mice, suggesting it as a potential improved tracer for demyelination imaging.

Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer 3F4AP

This study shows that isoflurane anesthesia inhibits [18F]3F4AP metabolism in mice, leading to higher brain uptake, similar to human studies, and highlights the need to consider anesthesia effects in PET tracer translation.

Evaluation of the potassium channel tracer 3F4AP in rhesus macaques

This study evaluates the PET tracer [18F]3F4AP in rhesus macaques for detecting demyelination, showing higher sensitivity than existing tracers and MRI methods.