Author

Ramesh Neelamegam

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 2 Organism:non-human primate· 2 Organism:rat· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Georges El FakhriiD· 3 shared Maëva DhaynautiD· 3 shared Marc D. NormandiniD· 3 shared Nicolas J. GuehliD· 3 shared Sung‐Hyun MooniD· 3 shared Pedro BrugarolasiD· 2 shared Anna‐Liisa BrownelliD· 1 shared Brian PopkoiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Georges El FakhriORCID

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3 papers

Recent·Most cited

PET imaging studies to investigate functional expression of mGluR2 using mG2P001

Gengyang Yuan, Maëva Dhaynaut, Nicolas J. Guehl, Ramesh Neelamegam, Sung‐Hyun Moon, Xiying Qu, Pekka Poutiainen, Sepideh Afshar, Georges El Fakhri, Anna‐Liisa Brownell, Marc D. Normandin

The paper investigates the functional expression of mGluR2 using PET imaging with [11C]mG2P001, showing increased accumulation with pretreatment and validating its use as a biomarker.

Journal of Cerebral Blood Flow & Metabolism · Sep 28, 2022Peer-reviewedNeuroscience

Radiochemical synthesis and evaluation in nonhuman primates of 3-methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS

Nicolas J. Guehl, Ramesh Neelamegam, Yu‐Peng Zhou, Sung‐Hyun Moon, Maëva Dhaynaut, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas

This paper develops and evaluates [11C]3MeO4AP, a PET tracer for imaging potassium channels in the CNS, showing high brain permeability, metabolic stability, and sensitivity to brain injury.

ACS Chemical Neuroscience · Feb 4, 2021Peer-reviewedNeuroscience

Evaluation of the potassium channel tracer 3F4AP in rhesus macaques

Nicolas J. Guehl, Karla M. Ramos‐Torres, Clas Linnman, Sung‐Hyun Moon, Maëva Dhaynaut, Moses Q. Wilks, Paul Kyu Han, Chao Ma, Ramesh Neelamegam, Yu-Peng Zhou, Brian Popko, John A. Correia, Daniel S. Reich, Georges El Fakhri, Peter Herscovitch, , Pedro Brugarolas

This study evaluates the PET tracer [18F]3F4AP in rhesus macaques for detecting demyelination, showing higher sensitivity than existing tracers and MRI methods.

Journal of Cerebral Blood Flow & Metabolism · Oct 22, 2020Peer-reviewedNeuroscience