Joshua C. Bufton

This paper develops NanoPilot, a modular fusion protein platform to redirect lipid nanoparticles (LNPs) away from the liver and toward specific cell types, improving transfection efficiency in T-cells and reducing off-target uptake.

This study identifies UPF2's RNA-binding and unfolding activities, showing its role in stabilizing single-stranded RNA and supporting NMD factor interactions.

This paper reveals the structural basis of KCTD1's pentameric assembly and TFAP2A binding, identifying a novel ion-binding channel involved in its function.

The paper engineers ADDobody protein scaffolds to generate high-avidity ADDomer super-binders through genetic modification and structural validation.