Julia W. Nalwalk

This study identifies LRRC8A/D-containing VRACs as the main pathway for swelling-activated taurine release in the brain but shows this pathway is not essential for systemic osmoregulation.

The paper investigates the subunit composition and functional roles of LRRC8 proteins in determining glutamate permeability of astrocytic VRACs using genetic and molecular approaches.

This study shows that deleting LRRC8A in the brain reduces stroke damage without affecting glutamate release, challenging the idea that VRACs contribute to stroke via glutamate release.

This study shows that brain-specific deletion of LRRC8A in mice leads to early mortality due to seizures, astrogliosis, and amino acid neurotransmitter dysregulation.