Author

Andrew N. Lowell

University of MichiganORCID 0000-0001-5357-5279Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:plant (other)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron M. KeeleriD· 1 shared Anastazja M KiselkaiD· 1 shared Anne M. BrowniD· 1 shared Cole GannettiD· 1 shared David H. ShermaniD· 1 shared Edward KalkreuteriD· 1 shared Gavin J. WilliamsiD· 1 shared James Weger‐LucarelliiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperSynthetic Biology

Aaron M. KeelerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Development of semisynthetic blasticidin S analogs with potent and fast-killing anti-malarial activity

Katherine R. Fike, Cole Gannett, Anastazja M Kiselka, Kateland Tiller, Toheeb Olakunle Ajasa, James Weger‐Lucarelli, Anne M. Brown, Andrew N. Lowell, Michael Klemba

This study develops semisynthetic blasticidin S analogs with higher anti-malarial potency and selectivity than the natural product.

ACS Infectious Diseases · Aug 1, 2026Peer-reviewedMicrobiology

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Edward Kalkreuter, Kyle S. Bingham, Aaron M. Keeler, Andrew N. Lowell, Jennifer J. Schmidt, David H. Sherman, Gavin J. Williams

The paper identifies key residues in an acyltransferase that influence substrate selectivity and demonstrates how swapping structural motifs can alter substrate specificity in polyketide synthases.

Nature Communications · Apr 13, 2021Peer-reviewedSynthetic Biology